Searchable abstracts of presentations at key conferences in endocrinology

ea0021oc2.5 | Neuroendocrine tumours/pituitary | SFEBES2009

Differential effects of oestrogen on hypothalamic GnRH-I and GnRH-II gene expression in female rhesus macaques

Urbanski Henryk , Eghlidi Dominique , Kohama Steven

In mammals, the preovulatory LH surge is thought to be triggered by enhanced release of GnRH into the hypothalamic–pituitary portal blood vessels. Recently, we discovered that the medial basal hypothalamus (MBH) of rhesus macaques (Macaca mulatta) contains two distinct populations of GnRH-producing neurones. One of these populations expresses the traditional mammalian form of GnRH (i.e. GnRH-I) while the other expresses a more conserved vertebrate form of GnRH (i.e...